Ketoneurology Educational evidence curation. No individual medical advice.

References and source notes

Evidence Library

A selected bibliography for the condition pages. The site emphasizes human clinical evidence where it exists, then clearly marks feasibility, mechanistic, or preclinical work.

This is a curated starting point, not a systematic review.

Epilepsy

Established in selected drug-resistant epilepsy

  1. Ketogenic diets for drug-resistant epilepsy Cochrane Database of Systematic Reviews, 2020
  2. Optimal clinical management of children receiving dietary therapies for epilepsy Epilepsia Open, 2018
  3. International recommendations for adults treated with ketogenic diet therapies Neurology Clinical Practice, 2021
  4. Classic ketogenic diet versus further antiseizure medicine in infants with drug-resistant epilepsy The Lancet Neurology, 2023
  5. Ketogenic diet therapy leads to antiseizure medication reduction in children and adults with drug-resistant epilepsy CNS Neuroscience & Therapeutics, 2024
  6. The ketogenic diet and potential micronutrient risks in drug-resistant epilepsy management Nutrients, 2026

Alzheimer's

Emerging clinical evidence

  1. Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease Alzheimer's Research & Therapy, 2021
  2. Medium-chain triglycerides for the symptomatic treatment of dementia-related diseases Journal of Nutrition and Metabolism, 2024
  3. Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans Alzheimer's & Dementia, 2025
  4. Ketogenic approaches for the treatment of Alzheimer's disease Current Opinion in Clinical Nutrition and Metabolic Care, 2024
  5. The impact of the ketogenic diet on Alzheimer's disease progression Nutrients, 2026
  6. Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer's disease Molecular Neurodegeneration, 2025

MS

Emerging supportive evidence

  1. Fasting, ketogenic, and anti-inflammatory diets in multiple sclerosis: final results of the NAMS trial Neurological Research and Practice, 2025
  2. Phase II study of ketogenic diets in relapsing multiple sclerosis Journal of Neurology, Neurosurgery & Psychiatry, 2022
  3. Dietary interventions in multiple sclerosis: a network meta-analysis PubMed record, 2024
  4. Serum neurofilament light chain in relapsing multiple sclerosis patients on a ketogenic diet Multiple Sclerosis Journal, 2023
  5. Impact of a ketogenic diet on sleep quality in people with relapsing multiple sclerosis Multiple Sclerosis and Related Disorders, 2024
  6. Ketogenic diet in modulating inflammation in multiple sclerosis: systematic review and meta-analysis Nutrients, 2025
  7. Exploring the ketogenic diet as adjunctive therapy in multiple sclerosis Nutrients, 2025

Parkinson's

Pilot and feasibility evidence

  1. Low-fat versus ketogenic diet in Parkinson's disease: a randomized pilot trial Movement Disorders, 2018
  2. Ketogenic intervention with MCT supplementation in Parkinson's disease BMC Neurology, 2024
  3. Randomized safety and feasibility crossover trial of two Mediterranean-ketogenic interventions in Parkinson's disease Frontiers in Nutrition, 2026
  4. Ketogenic interventions in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease Frontiers in Neurology, 2023
  5. Impact of a keto diet on symptoms of Parkinson's disease, biomarkers, depression, anxiety and quality of life Neurological Sciences, 2024
  6. Nutritional ketosis in Parkinson's disease: remaining questions and insights Current Nutrition Reports, 2021

Brain cancers

Adjunctive and investigational

  1. Efficacy and safety of ketogenic diet in glioblastoma: updated systematic review and meta-analysis Neurological Sciences, 2026
  2. Phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for newly diagnosed glioblastoma Neuro-Oncology Advances, 2025
  3. Ketogenic metabolic therapy as an adjuvant to standard care in glioblastoma: systematic review of clinical trials Nutrients, 2025
  4. Ketogenic diet therapy for high-grade gliomas combined with standard treatment using an angiogenesis inhibitor Nutrients, 2026
  5. Systematic review and clinical insights: ketogenic diet in glioblastoma cancer neuroscience Journal of Personalized Medicine, 2024
  6. Clinical framework for ketogenic metabolic therapy in glioblastoma PubMed record, 2024

Stroke

Preclinical and feasibility evidence

  1. Ketogenic diet and brain health: cerebrovascular mechanisms, neuroprotection, and translational implications Nutrients, 2026
  2. Ketogenic diet and ketone bodies against ischemic injury International Journal of Molecular Sciences, 2023
  3. Beta-hydroxybutyrate improves glymphatic system function and alleviates cerebral edema after ischemic stroke Journal of Neuroinflammation, 2025
  4. Brain transcriptome, microbiome and metabolome in ketogenic diet and experimental stroke Nutrients, 2024
  5. Beta-hydroxybutyrate mitigates sensorimotor and cognitive impairments in photothrombosis-induced ischemic stroke Nutrients, 2024
  6. Inducing ketogenesis via an enteral formulation in acute brain injury Critical Care, 2020